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Researchers have produced the first direct evidence that parts of our brains implicated in mental disorders may be shaped by a “residual echo” from our ancient past. Star-shaped support brain cells, astrocytes, growing in 3-D “organoids” in a dish develop similarly as those in human brain tissue. Schizophrenia-like gene expression changes modeled in human neurons matched changes found in patients’ brains. NIMH-funded scientists have discovered a pattern in the way a brain circuit works that may help predict the onset of psychosis. The new study included more than 62,000 people in Finland who had received a schizophrenia diagnosis at some time between 1972 and 2014. New Approach Advised to Treat Schizophrenia John Kane, chairman of the psychiatry department at Hofstra North Shore-LIJ School of Medicine, who led a study on the treatment of schizophrenia. Long overlooked as a mere “relay,” an egg-like structure in the middle of the brain also turns out to play a pivotal role in tuning-up thinking circuity. This also includes a discussion of family and personal history. READ. Real-world digital implementation of the Psychosis ... A waitlist-controlled pilot study of a novel psychological intervention to target illness engulfment in enduring schizophrenia … Recent studies applying new genomic technology to large samples have yielded substantial advances in identifying specific, associated DNA variants as well as clarifying the underlying genetic architecture of the disorder. Physical exam. The main purpose of this study was to test the applicability of the new SST to measure the ToM skills of persons with schizophrenia. Recent studies have found that acetaminophen is the leading cause of liver damage and probably is responsible for 1600 cases of acute liver failure that occur each year. Diagnosis of schizophrenia involves ruling out other mental health disorders and determining that symptoms are not due to substance abuse, medication or a medical condition. Since working memory function is often disturbed in mental disorders, such gene-hormone interactions are suspect mechanisms that may confer risk. People with schizophrenia in poorer nations are more prone to vitamin deficiency pellagra, reports a new study. The international group of study participants included 307 schizophrenia patients and 364 healthy controls, all of whom were 45-years … Posted: Thursday, October 8, 2020. 20, NO. It was first hypothesised in the early 1980s that schizophrenia was caused by dysfunctional synapses - where the nerve signals are transmitted between neurons in the brain. Schizophrenia Is 80% Genetic, According to This Massive New Study on Twins. Recent emphasis on dimensional approaches and translational bio-behavioral research domain criteria may eventually help move toward a neuroscience-based definition of schizophrenia… A groundbreaking brain-scanning technique has uncovered evidence that suggests schizophrenia is linked to a loss of connections between brain cells. A trio of studies in mice are revealing that the thalamus sustains the ability to distinguish categories and hold thoughts in mind. A new study, using … People with schizophrenia require lifelong treatment. Scientists have deciphered the molecular structure of a widely-prescribed antipsychotic docked in its key human brain receptor. However, several recent studies have found no evidence for an association between OCs and risk for schizophrenia [26, 27]. The research not only reveals a correlation, but hypothesizes the microbiome potentially … The findings of the study are published in the journal Schizophrenia Research . Recent findings: We performed an electronic database search for articles on ECT and schizophrenia, published in 2017. However, in recent years, scientists have observed that people who have recently been diagnosed with schizophrenia and who aren’t on any medication yet show evidence of physiological … Recent findings: Newer studies continue to suggest that early-onset schizophrenia (EOS) and LOS share fundamental clinical features (i.e., positive symptoms, negative symptoms, functional deficits). The researchers, who conducted the scans at the psychiatric imaging facility at the Medical Research Council (MRC) London Institute of Medical Sciences, say these changes could underlie the cognitive difficulties seen in schizophrenia and provide targets for research into new treatments. The doctor may also request imaging studies, such as an MRI or CT scan. A new study out of Poland’s Medical University of Lodz has found that 6 months of use of a nutritional supplement called sarcosine (N-Methylglycine) seems to reverse the damage to the brain’s glutamate system and improves the negative and cognitive symptoms (memory, concentration, social activity interest, motivation, etc. ) To develop better treatments in the future we need studies like this to shine a light on how the extraordinarily complex wiring of the human brain is altered by this disease. Cannabis and schizophrenia: New evidence unveiled The nature of the relationship between cannabis and psychiatric disorders has been hotly debated for decades. Brain scans reveal that fluctuations in estrogen can trigger atypical functioning in a key brain memory circuit in women with a common version of a gene. Contact Us. However, researchers had only been able to study this indirectly, such as in post mortem brains samples, or animal and cell models in the lab. This suggests that loss of synapses could underlie the development of schizophrenia. Synaptic loss is thought to underlie these symptoms. Read more. The main themes of these articles are: epidemiological data on ECT use from various countries; retrospective studies, prospective studies and meta-analyses focusing on efficacy and cognitive side-effects of ECT in schizophrenia; ECT technical parameters and potential biomarkers. Mental health research center directors emerged from a recent meeting with a renewed commitment to help each other achieve their common mission – to transform care of children, adolescents and adults with severe psychiatric disorders. Available in English and Español. A similar study showed that cases of schizophrenia decreased in the early 70s just as marijuana use exploded, and another study showed how schizophrenia cases increased just after marijuana use decreased in the late 80s into the early 90s. READ. New research concluded from a small study of schizophrenia patients referred to the Johns Hopkins Early Psychosis Intervention Clinic (EPIC) found that about half didn’t have the disease at all. Researchers have shown that a type of magnetic resonance imaging — called neuromelanin-sensitive MRI (NM-MRI) — is a potential biomarker for psychosis. Gene expression regulators work together to raise an individual’s risk of developing schizophrenia. “By studying the genome, we are getting a better handle on the genetic variations that are making people vulnerable to psychiatric disease,” said NIMH Director Thomas Insel, whose institute helped fund the study. of people who have schizophrenia. Researchers looked at people aged 16-30 and found that the group died at a rate at least 24 times greater than the same age group in the general population. New brain research suggests that schizophrenia is an extreme version of a common personality type by University of Nottingham MEG scanner … A new study in rodents has demonstrated, for the first time, that the brain’s cerebellum plays a role in controlling reward and social preference behavior—findings that shed light on the brain circuits critical to the affective and social dysfunction seen across multiple psychiatric disorders. Researchers have shown that a type of magnetic resonance imaging — called neuromelanin-sensitive MRI (NM-MRI) — is a potential biomarker for psychosis. Transforming the understanding and treatment of mental illnesses. As many as four out of five cases of schizophrenia can be traced back to genes … "We need to develop new treatments for schizophrenia. This large ongoing study at NIMH investigates the neurobiology of schizophrenia by identifying susceptibility genes, evaluating their impact on brain function to … EurekAlert! 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